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Total publications for 2019: 59

Huangfu P, Laurence Y V, Alisjahbana B, Ugarte-Gil C, Riza A-L, Walzl G, Ruslami R, Moore D a J, Ioana M, McAllister S, Ronacher K, Koesoemadinata R C, Grint D, Kerry S, Coronel J, Malherbe S T, Griffiths U, Dockrell H M, Hill P C, van Crevel R, Pearson F and Critchley J A. Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries. Int. J. Tuberc. Lung Dis. (2019) 23:283-292.

Abrahams S, Haylett W L, Johnson G, Carr J A and Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience (2019) 406:1-21.

Leisching G, Cole V, Ali A T and Baker B. OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion. Int. J. Infect. Dis. (2019) 80S:S77-S84.

Schurz H, Müller S J, van Helden P D, Tromp G, Hoal E G, Kinnear C J and Möller M. Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population. Front Genet (2019) 10:34.

Uche-Okereafor N, Sebola T, Tapfuma K, Mekuto L, Green E and Mavumengwana V. Antibacterial Activities of Crude Secondary Metabolite Extracts from Pantoea Species Obtained from the Stem of Solanum mauritianum and Their Effects on Two Cancer Cell Lines. Int J Environ Res Public Health (2019) 16.

Miller M A, Buss P, Roos E O, Hausler G, Dippenaar A, Mitchell E, van Schalkwyk L, Robbe-Austerman S, Waters W R, Sikar-Gang A, Lyashchenko K P, Parsons S D C, Warren R and van Helden P. Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife. Front Vet Sci (2019) 6:18.

Adesokan H K, Streicher E M, van Helden P D, Warren R M and Cadmus S I B. Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria. PLoS ONE (2019) 14:e0211637.

Goboza M, Aboua Y G, Chegou N and Oguntibeju O O. Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats. Biomed. Pharmacother. (2019) 112:108638.

Bulabula A N H, Nelson J A, Musafiri E M, Machekano R, Sam-Agudu N A, Diacon A H, Shah M, Creswell J, Theron G, Warren R M, Jacobson K R, Chirambiza J-P, Kalumuna D, Bisimwa B C, Katoto P D M C, Kaswa M K, Birembano F M, Kitete L, Grobusch M P, Kashongwe Z M and Nachega J B. Prevalence, Predictors, and Successful Treatment Outcomes of Xpert MTB/RIF-identified Rifampicin-resistant Tuberculosis in Post-conflict Eastern Democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study. Clin. Infect. Dis. (2019).

Motaung B, Walzl G and Loxton A G. The level of the endoplasmic reticulum stress chaperone protein, binding immunoglobulin protein (BiP), decreases following successful tuberculosis treatment. Int. J. Infect. Dis. (2019) 81:198-202.

Di Tanna G L, Khaki A R, Theron G, McCarthy K, Cox H, Mupfumi L, Trajman A, Zijenah L S, Mason P, Bandason T, Durovni B, Bara W, Hoelscher M, Clowes P, Mangu C, Chanda D, Pym A, Mwaba P, Cobelens F, Nicol M P, Dheda K, Churchyard G, Fielding K and Metcalfe J Z. Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis. Lancet Glob Health (2019) 7:e191-e199.

Matumba M G, Ayeleso A O, Nyakudya T, Erlwanger K, Chegou N N and Mukwevho E. Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet. Nutrients (2019) 11.

Nemes E, Abrahams D, Scriba T J, Ratangee F, Keyser A, Makhethe L, Erasmus M, Mabwe S, Bilek N, Rozot V, Geldenhuys H, Hatherill M, Lempicki M D, Holm L L, Bogardus L, Ginsberg A M, Blauenfeldt T, Smith B, Ellis R D, Loxton A G, Walzl G, Andersen P and Ruhwald M. Diagnostic accuracy of ESAT-6 free IGRA compared to QuantiFERON-TB Gold In-tube. Clin. Infect. Dis. (2019).

Schurz H, Salie M, Tromp G, Hoal E G, Kinnear C J and Möller M. The X chromosome and sex-specific effects in infectious disease susceptibility. Hum. Genomics (2019) 13:2.

Wasserman S, Denti P, Brust J C M, Abdelwahab M, Hlungulu S, Wiesner L, Norman J, Sirgel F A, Warren R M, Esmail A, Dheda K, Gandhi N R, Meintjes G and Maartens G. Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection. Antimicrob. Agents Chemother. (2019) 63.

Neethling A, Engelbrecht L, Loos B, Kinnear C, Theart R, Abrahams S, Niesler T, Mellick G D, Williams M and Bardien S. Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex. Exp. Cell Res. (2019) 375:72-79.

Fitzgerald B L, Islam M N, Graham B, Mahapatra S, Webb K, Boom W H, Malherbe S T, Joloba M L, Johnson J L, Winter J, Walzl G and Belisle J T. Elucidation of a Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy. ACS Infect Dis (2019) 5:353-364.

Ley S D, de Vos M, Van Rie A and Warren R M. Deciphering Within-Host Microevolution of Mycobacterium tuberculosis through Whole-Genome Sequencing: the Phenotypic Impact and Way Forward. Microbiol. Mol. Biol. Rev. (2019) 83.

Naidoo C C, Nyawo G R, Wu B G, Walzl G, Warren R M, Segal L N and Theron G. The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda. Lancet Respir Med (2019).

Ngwane A H, Petersen R-D, Baker B, Wiid I, Wong H N and Haynes R K. The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug. IUBMB Life (2019) 71:532-538.

Pohlin F, Buss P, Miller M, Steenkamp G, Gleed R, Poore L, Boesch J and Zeiler G. Etorphine-Ketamine Constant Rate Infusion for Maintenance of Anaesthesia in a Compromised White Rhinoceros (Ceratotherium simum). Case Rep Vet Med (2019) 2019:4309043.

Chileshe J, Goosen W J, Buss P E, van Helden P D, Warren R, Parsons S D C and Miller M A. A commercial ELISA for detection of interferon-gamma in white rhinoceros. J. Vet. Diagn. Invest. (2019):1040638719843955.

Edwards T L, Giri A, Hellwege J N, Hartmann K E, Stewart E A, Jeff J M, Bray M J, Pendergrass S A, Torstenson E S, Keaton J M, Jones S H, Gogoi R P, Kuivaniemi H, Jackson K L, Kho A N, Kullo I J, McCarty C A, Im H K, Pacheco J A, Pathak J, Williams M S, Tromp G, Kenny E E, Peissig P L, Denny J C, Roden D M and Velez Edwards D R. A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids. Front Genet (2019) 10:511.

Loxton A G. Bcells and their regulatory functions during Tuberculosis: Latency and active disease. Mol. Immunol. (2019) 111:145-151.

Ugarte-Gil C, Alisjahbana B, Ronacher K, Riza A L, Koesoemadinata R C, Malherbe S T, Cioboata R, Llontop J C, Kleynhans L, Lopez S, Santoso P, Marius C, Villaizan K, Ruslami R, Walzl G, Panduru N M, Dockrell H M, Hill P C, Mc Allister S, Pearson F, Moore D A J, Critchley J A, van Crevel R and TANDEM Consortium . Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study. Clin. Infect. Dis. (2019).

Penn-Nicholson A, Hraha T, Thompson E G, Sterling D, Mbandi S K, Wall K M, Fisher M, Suliman S, Shankar S, Hanekom W A, Janjic N, Hatherill M, Kaufmann S H E, Sutherland J, Walzl G, De Groote M A, Ochsner U, Zak D E, Scriba T J and ACS and GC6–74 cohort study groups . Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study. PLoS Med. (2019) 16:e1002781.

Mogashoa T, Melamu P, Ley S D, Streicher E M, Iketleng T, Kelentse N, Mupfumi L, Mokomane M, Kgwaadira B, Novitsky V, Kasvosve I, Moyo S, Warren R M and Gaseitsiwe S. Genetic diversity of Mycobacterium tuberculosis strains circulating in Botswana. PLoS ONE (2019) 14:e0216306.

Miller M A, Buss P, Sylvester T T, Lyashchenko K P, deKlerk-Lorist L-M, Bengis R, Hofmeyr M, Hofmeyr J, Mathebula N, Hausler G, Helden P v, Stout E, Parsons S D C and Olea-Popelka F. MYCOBACTERIUM BOVIS IN FREE-RANGING LIONS (PANTHERA LEO) - EVALUATION OF SEROLOGICAL AND TUBERCULIN SKIN TESTS FOR DETECTION OF INFECTION AND DISEASE. J. Zoo Wildl. Med. (2019) 50:7-15.

Vrieling F, Wilson L, Rensen P C N, Walzl G, Ottenhoff T H M and Joosten S A. Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction. PLoS Pathog. (2019) 15:e1007724.

Pooran A, Theron G, Zijenah L, Chanda D, Clowes P, Mwenge L, Mutenherwa F, Lecesse P, Metcalfe J, Sohn H, Hoelscher M, Pym A, Peter J, Dowdy D and Dheda K. Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation. Lancet Glob Health (2019) 7:e798-e807.

Moore D K and Loxton A G. Regulatory B lymphocytes: development and modulation of the host immune response during disease. Immunotherapy (2019) 11:691-704.

Edwards K L, Miller M A, Carlstead K and Brown J L. Relationships between housing and management factors and clinical health events in elephants in North American zoos. PLoS ONE (2019) 14:e0217774.

Kerr T J, de Waal C R, Buss P E, Hofmeyr J, Lyashchenko K P and Miller M A. Seroprevalence of Mycobacterium tuberculosis Complex in Free-ranging African Elephants (Loxodonta africana) in Kruger National Park, South Africa. J. Wildl. Dis. (2019).

Shahbaaz M, Cloete R, Grobbelaar M, Sampson S and Christoffels A. Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study. Int. J. Biol. Macromol. (2019) 135:582-590.


Magcwebeba T, Dorhoi A and du Plessis N. The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis. Front Immunol (2019) 10:917.

Sao Emani C, Gallant J L, Wiid I J and Baker B. The role of low molecular weight thiols in Mycobacterium tuberculosis. Tuberculosis (Edinb) (2019) 116:44-55.

Kuivaniemi H and Tromp G. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene (2019) 707:151-171.

Meehan C J, Goig G A, Kohl T A, Verboven L, Dippenaar A, Ezewudo M, Farhat M R, Guthrie J L, Laukens K, Miotto P, Ofori-Anyinam B, Dreyer V, Supply P, Suresh A, Utpatel C, van Soolingen D, Zhou Y, Ashton P M, Brites D, Cabibbe A M, de Jong B C, de Vos M, Menardo F, Gagneux S, Gao Q, Heupink T H, Liu Q, Loiseau C, Rigouts L, Rodwell T C, Tagliani E, Walker T M, Warren R M, Zhao Y, Zignol M, Schito M, Gardy J, Cirillo D M, Niemann S, Comas I and Van Rie A. Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues. Nat. Rev. Microbiol. (2019).

de Vos M, Ley S D and Cox H. Bedaquiline micro-heteroresistance after tuberculosis treatment cessation.. N Engl J Med (2019).

Khan P Y, Yates T A, Osman M, Warren R M, van der Heijden Y, Padayatchi N, Nardell E A, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling A C, Mizrahi V, Rustomjee R and Pym A. Transmission of drug-resistant tuberculosis in HIV-endemic settings. Lancet Infect Dis (2019) 19:e77-e88.

Ronacher K, Chegou N N, Kleynhans La, Djoba Siawaya J F, du Plessis N, Loxton A G, Maasdorp E, Tromp G, Kidd M, Stanley K, Kriel M, Menezes A, Gutschmidt A, van der Spuy G D, Warren R M, Dietze R, Okwera A, Thiel B, Belisle J T, Cliff J M, Boom W H, Johnson J L, van Helden P D, Dockrell H M and Walzl G. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis (Edinb) (2019) 118:101859.

Duffy F J, Weiner J, Hansen S, Tabb D L, Suliman S, Thompson E, Maertzdorf J, Shankar S, Tromp G, Parida S, Dover D, Axthelm M K, Sutherland J S, Dockrell H M, Ottenhoff T H M, Scriba T J, Picker L J, Walzl G, Kaufmann S H E, Zak D E and GC6-74 Consortium . Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome. Front Immunol (2019) 10:527.

Bernitz N, Kerr T J, Goosen W J, Higgitt R L, de Waal C, Clarke C, Cooper D V, Warren R M, van Helden P D, Parsons S D C and Miller M A. Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer). Vet. Immunol. Immunopathol. (2019) 217:109923.

Chileshe J, Roos E O, Goosen W J, Buss P, Hausler G, Rossouw L, Manemela T, van Helden P, Warren R, Parsons S D and Miller M. An interferon-gamma release assay for the diagnosis of the Mycobacterium bovis infection in white rhinoceros (Ceratotherium simum). Vet. Immunol. Immunopathol. (2019) 217:109931.

Dheda K, Gumbo T, Maartens G, Dooley K E, Murray M, Furin J, Nardell E A, Warren R M and Lancet Respiratory Medicine drug-resistant tuberculosis Commission group . The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis. Lancet Respir Med (2019) 7:820-826.

Dippenaar A, De Vos M, Marx F M, Adroub S A, van Helden P D, Pain A, Sampson S L and Warren R M. Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting. Infect. Genet. Evol. (2019) 75:103948.

Feliciano C S, Menon L J B, Anselmo L M P, Dippenaar A, Warren R M, Silva W A and Bollela V R. Xpert MTB/RIF performance to diagnose tuberculosis and rifampicin resistance in a reference centre in southern Brazil. ERJ Open Res (2019) 5.

Higgitt R L, Louis van Schalkwyk O, de Klerk-Lorist L-M, Buss P E, Caldwell P, Rossouw L, Manamela T, Hausler G A, Hewlett J, Mitchell E P, van Helden P D, Parsons S D C and Miller M A. Mycobacterium bovis Infection in African Wild Dogs, Kruger National Park, South Africa. Emerging Infect. Dis. (2019) 25:1425-1427.

Manngo P M, Gutschmidt A, Snyders C I, Mutavhatsindi H, Manyelo C M, Makhoba N S, Ahlers P, Hiemstra A, Stanley K, McAnda S, Kidd M, Malherbe S T, Walzl G and Chegou N N. Prospective evaluation of host biomarkers other than interferon gamma in QuantiFERON Plus supernatants as candidates for the diagnosis of tuberculosis in symptomatic individuals. J. Infect. (2019) 79:228-235.

Miller M A, Gortazar C, Roos E O, Risalde M A, Johnathan-Lee A, Sridhara A A and Lyashchenko K P. Serological reactivity to MPB83 and CFP10/ESAT-6 antigens in three suid hosts of Mycobacterium bovis infection. Vet. Microbiol. (2019) 235:285-288.

Mouton J M, Heunis T, Dippenaar A, Gallant J L, Kleynhans La and Sampson S L. Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37Rv. Front Microbiol (2019) 10:1922.

Murugesan K, Hogan C A, Palmer Z, Reeve B, Theron G, Andama A, Somoskovi A, Steadman A, Madan D, Andrews J, Croda J, Sahoo M K, Cattamanchi A, Pinsky B A and Banaei N. Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine. J. Clin. Microbiol. (2019) 57.

Ronacher K, Chegou N N, Kleynhans La, Djoba Siawaya J F, du Plessis N, Loxton A G, Maasdorp E, Tromp G, Kidd M, Stanley K, Kriel M, Menezes A, Gutschmidt A, van der Spuy G D, Warren R M, Dietze R, Okwera A, Thiel B, Belisle J T, Cliff J M, Boom W H, Johnson J L, van Helden P D, Dockrell H M and Walzl G. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis (Edinb) (2019) 118:101859.

Sebola T E, Uche-Okereafor N C, Tapfuma K I, Mekuto L, Green E and Mavumengwana V. Evaluating antibacterial and anticancer activity of crude extracts of bacterial endophytes from Crinum macowanii Baker bulbs. Microbiologyopen (2019):e914.

Shang A, Cao S-Y, Xu X-Y, Gan R-Y, Tang G-Y, Corke H, Mavumengwana V and Li H-B. Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.). Foods (2019) 8.

Simba H, Kuivaniemi H, Lutje V, Tromp G and Sewram V. Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations. Front Genet (2019) 10:642.

Tavalire H F, Hoal E G, le Roex N, van Helden P D, Ezenwa V O and Jolles A E. Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host. Proc. Biol. Sci. (2019) 286:20190914.

Wang Q, Modongo C, Allender C, Engelthaler D M, Warren R M, Zetola N M and Shin S S. Utility of Targeted, Amplicon-Based Deep Sequencing To Detect Resistance to First-Line Tuberculosis Drugs in Botswana. Antimicrob. Agents Chemother. (2019) 63.